Publication Database

MicroRNA-15 family targets the hedgehog signaling pathway during postnatal development of porcine intestine (2019)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

zur Brügge, Jennifer (WE 3)

Bohmer, Marc (WE 3)

Hahn, Elisabeth (WE 3)

Steiner, Claudia (WE 3)

Einspanier, Ralf (WE 3)

Sharbati, Soroush (WE 3)

Quelle

Biochemical and biophysical research communications

Bandzählung: 508

Heftzählung: 3

Seiten: 832 – 837

ISSN: 0006-291x

Sprache

Englisch

Verweise

DOI: 10.1016/j.bbrc.2018.11.205

Pubmed: 30528739

Kontakt

Institut für Veterinär-Biochemie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62225
biochemie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The hedgehog signaling pathway is a crucial regulator of the postnatal intestinal development. Regulation of hedgehog expression itself is poorly understood. MicroRNAs were demonstrated to control differentiation and proliferation in postnatal intestinal development. This study identifies members of the miR-15 family to regulate the expression of key hedgehog factors employing in silico and in vitro experiments. Physiological relevance is demonstrated by incorporation of in vivo expression data from the ileum and colon from 7 to 56 days old piglets. Results presented in this study improve the understanding of the complex regulation of hedgehog signaling during intestinal development and disease.