Publication Database

Therapiemöglichkeiten bei Equinen Sarkoiden (2019)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Loschelder, Johanna (WE 17)

Winter, Judith (WE 17)

Gehlen, H. (WE 17)

Quelle

Pferdeheilkunde : offizielles Organ der DVG, Fachgruppe Pferdekrankheiten = Equine medicine

Bandzählung: 35

Heftzählung: 1

Seiten: 25 – 33

ISSN: 0177-7726

Verweise

URL (Volltext): http://www.hippiatrika.com/download.htm?id=20190104

DOI: 10.21836/PEM20190104

Kontakt

Pferdeklinik

Oertzenweg 19 b
14163 Berlin
+49 30 838 62299 / 62300
pferdeklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The equine sarcoid is a locally invasive growing, non-metastatic tumor of the equine skin. It is the most common skin tumor in the horse. The pathogenesis is poorly understood and many different factors seem to play a role. A genetic predisposition, vectors and contact of the skin with the bovine papillomavirus are known to influence the occurrence rate of equine sarcoids. Six different types of sarcoids have been described (occult, verrucous, nodular, fibroblastic, malevolent and mixed). Many treatment options are available but there is always a high risk of recurrence and failure of treatment is often followed by a more aggressive tumor growth. Owners should be advised carefully before any treatment and prognosis is guarded. The various available treatment options include surgical removal, cryosurgery, radiation therapy, chemotherapy, antiviral therapy, immunotherapy, phototherapy and phytotherapy. Study designs investigating these different therapy options differ (especially regarding observation periods and the definition of treatment success), which makes it difficult to compare treatments. None of the available therapies has been successful in all cases. Radiation therapy had the best outcome so far, but there are only few treatment centers and costs for treatment often exceeds €2000. If sarcoids show well-defined margins, surgical excision is a good option. A safety margin of at least 2 cm should be achieved. In cases where this is not possible, the tumor bed should be treated additionally with chemotherapy, for example with the injection of cisplatin. Periocular sarcoids responded well to BCG injections, but there is a small risk for fatal reactions. Mitomycin might be a good alternative for these cases. Other sarcoids can be treated with chemotherapy (for example with cisplatin injections). The combination with elektrochemotherapy showed promising results.