Publikationsdatenbank

Translational Animal Models of Atopic Dermatitis for Preclinical Studies (2017)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Martel, Britta C

Lovato, Paola

Bäumer, Wolfgang (WE 14)

Olivry, Thierry

Quelle

Yale journal of biology and medicine : YJBM

Bandzählung: 90

Heftzählung: 3

Seiten: 389 – 402

ISSN: 1551-4056

Sprache

Englisch

Verweise

URL (Volltext): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612183/

Pubmed: 28955179

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

There is a medical need to develop new treatments for patients suffering from atopic dermatitis (AD). To improve the discovery and testing of novel treatments, relevant animal models for AD are needed. Generally, these animal models mimic different aspects of the pathophysiology of human AD, such as skin barrier defects and Th2 immune bias with additional Th1 and Th22, and in some populations Th17, activation. However, the pathomechanistic characterization and pharmacological validation of these animal models are generally incomplete. In this paper, we review animal models of AD in the context of preclinical use and their possible translation to the human disease. Most of these models use mice, but we will also critically evaluate dog models of AD, as increasing information on disease mechanism show their likely relevance for the human disease.