Publikationsdatenbank

Manipulation of the balance between Th2 and Th2/1 hybrid cells affects parasite nematode fitness in mice (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Affinass, Nicole (WE 6)

Zhang, Hongwei (WE 6)

Löhning, Max

Hartmann, Susanne (WE 6)

Rausch, Sebastian (WE 6)

Quelle

European journal of immunology : basic, clinical, translational

Bandzählung: 48

Heftzählung: 12

Seiten: 1958 – 1964

ISSN: 1521-4141

Sprache

Englisch

Verweise

DOI: 10.1002/eji.201847639

Pubmed: 30267404

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

T helper type 2 (Th2) responses are central to the control of helminth infections, but sensitive to opposing cytokine signals favoring Th1 priming. We previously reported on GATA-3+ T-bet+ Th2/1 hybrid cell differentiation in helminth mono-infections, resulting in a substantial proportion of cells co-producing IFN-γ next to Th2 cytokines. Here we demonstrate Th2/1 cells as the major source of parasite-specific IFN-γ production in acute and chronic infections with the enteric nematode Heligmosomoides polygyrus. Th2/1 cells differentiated from naive precursors and accumulated in spleen and intestine of infected mice, resulting in increased systemic and mucosal IFN-γ production. IFN-γ supplementation early during infection supported Th2/1 differentiation, associated with elevated parasite fecundity and the maintenance of high worm burdens in the chronic stage of infection, whereas mice lacking IFN-γ signals generated poor Th2/1 responses and restricted parasite fecundity more efficiently. These findings suggest that Th2/1 hybrid responses take part in immune regulation during helminth infection and restrain effective anti-helminth immunity. This article is protected by copyright. All rights reserved.