Publikationsdatenbank

Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Costantini, David

Seeber, Peter A

Soilemetzidou, Sanatana-Eirini

Azab, Walid (WE 5)

Bohner, Julia

Buuveibaatar, Bayarbaatar

Czirják, Gábor Á

East, Marion L

Greunz, Eva Maria

Kaczensky, Petra

Lamglait, Benjamin

Melzheimer, Jörg

Uiseb, Kenneth

Ortega, Alix

Osterrieder, Nikolaus (WE 5)

Sandgreen, Ditte-Mari

Simon, Marie

Walzer, Chris

Greenwood, Alex D (WE 5)

Quelle

Scientific reports

Bandzählung: 8

Heftzählung: 10347

Seiten: 1 – 10

ISSN: 2045-2322

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41598-018-28688-0

DOI: 10.1038/s41598-018-28688-0

Pubmed: 29985431

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Viruses may have a dramatic impact on the health of their animal hosts. The patho-physiological mechanisms underlying viral infections in animals are, however, not well understood. It is increasingly recognized that oxidative stress may be a major physiological cost of viral infections. Here we compare three blood-based markers of oxidative status in herpes positive and negative individuals of the domestic horse (Equus ferus caballus) and of both captive and free-ranging Mongolian khulan (Equus hemionus hemionus) and plains zebra (Equus quagga). Herpes positive free-ranging animals had significantly more protein oxidative damage and lower glutathione peroxidase (antioxidant enzyme) than negative ones, providing correlative support for a link between oxidative stress and herpesvirus infection in free-living equids. Conversely, we found weak evidence for oxidative stress in herpes positive captive animals. Hence our work indicates that environment (captive versus free living) might affect the physiological response of equids to herpesvirus infection. The Mongolian khulan and the plains zebra are currently classified as near threatened by the International Union for Conservation of Nature. Thus, understanding health impacts of pathogens on these species is critical to maintaining viable captive and wild populations.