Publikationsdatenbank

Adaptation and conservation insights from the koala genome (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Johnson, Rebecca N

O'Meally, Denis

Chen, Zhiliang

Etherington, Graham J

Ho, Simon Y W

Nash, Will J

Grueber, Catherine E

Cheng, Yuanyuan

Whittington, Camilla M

Dennison, Siobhan

Peel, Emma

Haerty, Wilfried

O'Neill, Rachel J

Colgan, Don

Russell, Tonia L

Alquezar-Planas, David E

Attenbrow, Val

Bragg, Jason G

Brandies, Parice A

Chong, Amanda Yoon-Yee

Deakin, Janine E

Di Palma, Federica

Duda, Zachary

Eldridge, Mark D B

Ewart, Kyle M

Hogg, Carolyn J

Frankham, Greta J

Georges, Arthur

Gillett, Amber K

Govendir, Merran

Greenwood, Alex D (WE 5)

Hayakawa, Takashi

Helgen, Kristofer M

Hobbs, Matthew

Holleley, Clare E

Heider, Thomas N

Jones, Elizabeth A

King, Andrew

Madden, Danielle

Marshall Graves, Jennifer A

Morris, Katrina M

Neaves, Linda E

Patel, Hardip R

Polkinghorne, Adam

Renfree, Marilyn B

Robin, Charles

Salinas, Ryan

Tsangaras, Kyriakos

Waters, Paul D

Waters, Shafagh A

Wright, Belinda

Wilkins, Marc R

Timms, Peter

Belov, Katherine

Quelle

Nature genetics

Bandzählung: 50

Heftzählung: 8

Seiten: 1102 – 1111

ISSN: 1061-4036

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41588-018-0153-5

DOI: 10.1038/s41588-018-0153-5

Pubmed: 29967444

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala's ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala's survival in the wild.