Publikationsdatenbank

Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Zepeda Mendoza, M Lisandra

Xiong, Zijun

Escalera-Zamudio, Marina

Runge, Anne Kathrine

Thézé, Julien

Streicker, Daniel

Frank, Hannah K

Loza-Rubio, Elizabeth

Liu, Shengmao

Ryder, Oliver A

Samaniego Castruita, Jose Alfredo

Katzourakis, Aris

Pacheco, George

Taboada, Blanca

Löber, Ulrike

Pybus, Oliver G

Li, Yang

Rojas-Anaya, Edith

Bohmann, Kristine

Carmona Baez, Aldo

Arias, Carlos F

Liu, Shiping

Greenwood, Alex D (WE 5)

Bertelsen, Mads F

White, Nicole E

Bunce, Michael

Zhang, Guojie

Sicheritz-Pontén, Thomas

Gilbert, M P Thomas

Quelle

Nature ecology & evolution

Bandzählung: 2

Heftzählung: 4

Seiten: 659 – 668

ISSN: 2397-334x

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41559-018-0476-8

DOI: 10.1038/s41559-018-0476-8

Pubmed: 29459707

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.