Publication Database

The role of type I interferons (IFNs) in the regulation of chicken macrophage inflammatory response to bacterial challenge (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Garrido, Damien

Alber, Andreas

Kut, Emmanuel

Chanteloup, Nathalie K

Lion, Adrien

Trotereau, Angélina

Dupont, Joëlle

Tedin, Karsten (WE 7)

Kaspers, Bernd

Vervelde, Lonneke

Trapp, Sascha

Schouler, Catherine

Guabiraba, Rodrigo

Quelle

Developmental and comparative immunology

Bandzählung: 86

Seiten: 156 – 170

ISSN: 0145-305x

Sprache

Englisch

Verweise

DOI: 10.1016/j.dci.2018.04.025

Pubmed: 29729283

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mammalian type I interferons (IFNα/β) are known to modulate inflammatory processes in addition to their antiviral properties. Indeed, virus-induced type I interferons regulate the mammalian phagocyte immune response to bacteria during superinfections. However, it remains unresolved whether type I IFNs similarly impact the chicken macrophage immune response. We first evidenced that IFNα and IFNβ act differently in terms of gene expression stimulation and activation of intracellular signaling pathways in chicken macrophages. Next, we showed that priming of chicken macrophages with IFNα increased bacteria uptake, boosted bacterial-induced ROS/NO production and led to an increased transcriptional expression or production of NOS2/NO, IL1B/IL-1β and notably IFNB/IFNβ. Neutralization of IFNβ during bacterial challenge limited IFNα-induced augmentation of the pro-inflammatory response. In conclusion, we demonstrated that type I IFNs differently regulate chicken macrophage functions and drive a pro-inflammatory response to bacterial challenge. These findings shed light on the diverse functions of type I IFNs in chicken macrophages.