Publikationsdatenbank

How Host Specific Are Herpesviruses? Lessons from Herpesviruses Infecting Wild and Endangered Mammals (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Azab, Walid (WE 5)

Dayaram, Anisha

Greenwood, Alex D

Osterrieder, Nikolaus (WE 5)

Quelle

Annual review of virology

Bandzählung: 5

Seiten: aop

ISSN: 2327-0578

Sprache

Englisch

Verweise

DOI: 10.1146/annurev-virology-092917-043227

Pubmed: 30052491

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Herpesviruses are ubiquitous and can cause disease in all classes of vertebrates but also in animals of lower taxa, including molluscs. It is generally accepted that herpesviruses are primarily species specific, although a species can be infected by different herpesviruses. Species specificity is thought to result from host-virus coevolutionary processes over the long term. Even with this general concept in mind, investigators have recognized interspecies transmission of several members of the Herpesviridae family, often with fatal outcomes in non-definitive hosts-that is, animals that have no or only a limited role in virus transmission. We here summarize herpesvirus infections in wild mammals that in many cases are endangered, in both natural and captive settings. Some infections result from herpesviruses that are endemic in the species that is primarily affected, and some result from herpesviruses that cause fatal disease after infection of non-definitive hosts. We discuss the challenges of such infections in several endangered species in the absence of efficient immunization or therapeutic options. Expected final online publication date for the Annual Review of Virology Volume 5 is September 29, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.