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Treatment of chronic endometritis in dairy cows with cephapirin, tiaprost or a combination of both
Objective: Three protocols for the treatment of chronic endometritis in dairy cows were compared in a field trial.
Material and methods: A total of 173 cows with clinical signs of chronic endometritis diagnosed by external adspection and rectal palpation 21 to 27 days post partum were randomly assigned to one of three treatment groups.
Cows without endometritis were regarded as a healthy control group. In group A (n = 59) cows received an intrauterine treatment with 500 mg of cephapirin. The treatment of cows in group B (n = 68) consisted of two injections of 0.75 mg tiaprost in a 14-day interval. In group C (n = 46) cows were treated with cephapirin and received tiaprost
seven days later.
Results: Clinical cure rate 14 days after the first treatment was 71.2, 70.6 and 84.8% in groups A, B, and C, respectively (p > 0.05). No significant differences in reproductive performance measures could be found between group A, group B, and the healthy control group.
First service conception rate was significantly lower in group C compared to group B and the healthy control group. Total conception rate was significantly lower in
group C compared to all other groups.
Conclusion and clinical relevance: It is concluded that the treatment of
chronic endometritis in dairy cows with cephapirin or tiaprost is equally effective, while the combination of both treatments does not improve treatment efficacy.