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    Evaluation of predisposing factors for a long-time colonization of pigs with livestock-associated MRSA via the airbone route in a newly established animal model (2017)

    Art
    Vortrag
    Autoren
    Rosen, K. (WE 10)
    Ebner, F. (WE 6)
    Friese, A. (WE 10)
    Hartmann, S. (WE 6)
    Rösler, U. (WE 10)
    Kongress
    National Symposium on Zoonoses Research 2017
    12. – 13.10.2017
    Quelle
    National Symposium on Zoonoses Research 2017 — German Research Platform for Zoonoses (Hrsg.)
    — S. 101
    Sprache
    Englisch
    Verweise
    URL (Volltext): http://www.zoonosen.net/Desktopmodules/Bring2Mind/DMX/Download.aspx?EntryId=31102&PortalId=24
    Kontakt
    Institut für Tier- und Umwelthygiene

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14169 Berlin
    +49 30 838 51845
    tierhygiene@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Background and objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a concern in healthcare systems. The occurrence of livestock-associated MRSA is a common phenomenon in pigs and a spread via an airborne route was assumed.
    The aim of our ongoing study is to identify the dose for a successful airborne colonization of pigs with MRSA ST398 and to evaluate the impact of predisposing factors on MRSA colonization.
    Materials and methods: For this, we established an experimental aerogen infection model for pigs using an aerosol chamber and we following investigated the impact of a decreased systemic immunity on the La-MRSA infection rate.
    Results: All animals were colonised after the exposure with a dosage of 104 cfu/m3), followed by a dropping number of colonized animals until day 14 after infection. In contrast, all animals infected with 106 cfu/m3 were MRSA-positive for the entire screening period (21 days). Conclusion: These data indicate that an airborne route of MRSA exists. Moreover, our current data show that a general immunosuppression of piglets does not significantly influence a La-MRSA colonization of weaned piglets.