Fachbereich Veterinärmedizin



    Stratum Corneum Targeting by Dendritic Core-Multishell-Nanocarriers in a Mouse Model of Psoriasis (2017)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Pischon, Hannah (WE 12)
    Radbruch, Moritz (WE 12)
    Ostrowski, Anja
    Volz, Pierre
    Gerecke, Christian
    Unbehauen, Michael
    Hönzke, Stefan
    Hedtrich, Sarah
    Fluhr, Joachim W
    Haag, Rainer
    Kleuser, Burkhard
    Alexiev, Ulrike
    Gruber, Achim D (WE 12)
    Mundhenk, Lars (WE 12)
    Nanomedicine : nanotechnology, biology, and medicine; 13(1) — S. 317–327
    ISSN: 1549-9642
    DOI: 10.1016/j.nano.2016.09.004
    Pubmed: 27697619
    Institut für Tierpathologie

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    Abstract / Zusammenfassung

    Inflammatory disorders of the skin pose particular therapeutic challenges due to complex structural and functional alterations of the skin barrier. Penetration of several anti-inflammatory drugs is particularly problematic in psoriasis, a common dermatitis condition with epidermal hyperplasia and hyperkeratosis. Here, we tested in vivo dermal penetration and biological effects of dendritic core-multishell-nanocarriers (CMS) in a murine skin model of psoriasis and compared it to healthy skin. In both groups, CMS exclusively localized to the stratum corneum of the epidermis with only very sporadic uptake by Langerhans cells. Furthermore, penetration into the viable epidermis of nile red as a model for lipophilic compounds was enhanced by CMS. CMS proved fully biocompatible in several in vitro assays and on normal and psoriatic mouse skin. The observations support the concept of CMS as promising candidates for drug delivery in inflammatory hyperkeratotic skin disorders in vivo.