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    A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011-2014 (2017)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Rosner, Bettina M.
    Schielke, Anika
    Didelot, Xavier
    Kops, Friederike
    Breidenbach, Janina
    Willrich, Niklas
    Gölz, Greta (WE 8)
    Alter, Thomas (WE 8)
    Stingl, Kerstin
    Josenhans, Christine
    Suerbaum, Sebastian
    Stark, Klaus
    Forschungsprojekt
    FBI - ZOO: Untersuchungen zur Tenazität ausgewählter Campylobacter jejuni/coli- und Yersinia enterocolitica-Stämme in Lebensmittelmatrizen (TP 08)
    Quelle
    Scientific reports; 7(1) — S. 5139
    ISSN: 2045-2322
    Sprache
    Englisch
    Verweise
    DOI: 10.1038/s41598-017-05227-x
    Pubmed: 28698561
    Kontakt
    Institut für Lebensmittelsicherheit und -hygiene

    Königsweg 69
    14163 Berlin
    +49 30 838 62550
    lebensmittelhygiene@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Campylobacter infection is the most commonly notified bacterial enteritis in Germany. We performed a large combined case-control and source attribution study (Nov 2011-Feb 2014) to identify risk factors for sporadic intestinal Campylobacter infections and to determine the relative importance of various animal sources for human infections in Germany. We conducted multivariable logistic regression analysis to identify risk factors. Source attribution analysis was performed using the asymmetric island model based on MLST data of human and animal/food isolates. As animal sources we considered chicken, pig, pet dog or cat, cattle, and poultry other than chicken. Consumption of chicken meat and eating out were the most important risk factors for Campylobacter infections. Additional risk factors were preparation of poultry meat in the household; preparation of uncooked food and raw meat at the same time; contact with poultry animals; and the use of gastric acid inhibitors. The mean probability of human C. jejuni isolates to originate from chickens was highest (74%), whereas pigs were a negligible source for C. jejuni infections. Human C. coli isolates were likely to originate from chickens (56%) or from pigs (32%). Efforts need to be intensified along the food chain to reduce Campylobacter load, especially on chicken meat.