Fachbereich Veterinärmedizin



    Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity (2017)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Cândido, Flávia Galvão
    Valente, Flávia Xavier
    Grześkowiak, Łukasz Marcin (WE 4)
    Moreira, Ana Paula Boroni
    Rocha, Daniela Mayumi Usuda Prado
    Alfenas, Rita de Cássia Gonçalves
    International journal of food sciences and nutrition — S. 1–19
    ISSN: 0963-7486
    DOI: 10.1080/09637486.2017.1343286
    Pubmed: 28675945
    Institut für Tierernährung

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    Abstract / Zusammenfassung

    Dietary fat strongly affects human health by modulating gut microbiota composition and low-grade systemic inflammation. High-fat diets have been implicated in reduced gut microbiota richness, increased Firmicutes to Bacteroidetes ratio, and several changes at family, genus and species levels. Saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) and conjugated linolenic fatty acids share important pathways of immune system activation/inhibition with gut microbes, modulating obesogenic and proinflammatory profiles. Mechanisms that link dietary fat, gut microbiota and obesity are mediated by increased intestinal permeability, systemic endotoxemia, and the activity of the endocannabinoid system. Although the probiotic therapy could be a complementary strategy to improve gut microbiota composition, it did not show permanent effects to treat fat-induced dysbiosis. Based upon evidence to date, we believe that high-fat diets and SFA consumption should be avoided, and MUFA and omega-3 PUFA intake should be encouraged in order to regulate gut microbiota and inflammation, promoting body weight/fat control.