Publication Database

Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity (2017)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Cândido, Flávia Galvão

Valente, Flávia Xavier

Grześkowiak, Łukasz Marcin (WE 4)

Moreira, Ana Paula Boroni

Rocha, Daniela Mayumi Usuda Prado

Alfenas, Rita de Cássia Gonçalves

Quelle

International journal of food sciences and nutrition

Seiten: 1 – 19

ISSN: 0963-7486

Sprache

Englisch

Verweise

DOI: 10.1080/09637486.2017.1343286

Pubmed: 28675945

Kontakt

Institut für Tierernährung

Königin-Luise-Str. 49
14195 Berlin
+49 30 838 52256
tierernaehrung@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Dietary fat strongly affects human health by modulating gut microbiota composition and low-grade systemic inflammation. High-fat diets have been implicated in reduced gut microbiota richness, increased Firmicutes to Bacteroidetes ratio, and several changes at family, genus and species levels. Saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) and conjugated linolenic fatty acids share important pathways of immune system activation/inhibition with gut microbes, modulating obesogenic and proinflammatory profiles. Mechanisms that link dietary fat, gut microbiota and obesity are mediated by increased intestinal permeability, systemic endotoxemia, and the activity of the endocannabinoid system. Although the probiotic therapy could be a complementary strategy to improve gut microbiota composition, it did not show permanent effects to treat fat-induced dysbiosis. Based upon evidence to date, we believe that high-fat diets and SFA consumption should be avoided, and MUFA and omega-3 PUFA intake should be encouraged in order to regulate gut microbiota and inflammation, promoting body weight/fat control.