Publikationsdatenbank

Host-pathogen interactions in bacterial meningitis (2016)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Doran, Kelly S.

Fulde, Marcus (WE 7)

Gratz, Nina

Kim, Brandon J.

Nau, Roland

Prasadarao, Nemani

Schubert-Unkmeir, Alexandra

Tuomanen, Elaine I.

Valentin-Weigand, Peter

Quelle

Acta Neuropathology; 131(2) — S. 185–209

ISSN: 0001-6322

Sprache

Englisch

Verweise

DOI: 10.1007/s00401-015-1531-z

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
Gebäude 35
14163 Berlin
+49 30 838 51840 / 51843
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Bacterial meningitis is a devastating disease occurring worldwide with up to half of the survivors left with permanent neurological sequelae. Due to intrinsic properties of the meningeal pathogens and the host responses they induce, infection can cause relatively specific lesions and clinical syndromes that result from interference with the function of the affected nervous system tissue. Pathogenesis is based on complex host–pathogen interactions, some of which are specific for certain bacteria, whereas others are shared among different pathogens. In this review, we summarize the recent progress made in understanding the molecular and cellular events involved in these interactions. We focus on selected major pathogens, Streptococcus pneumonia, S. agalactiae (Group B Streptococcus), Neisseria meningitidis, and Escherichia coli K1, and also include a neglected zoonotic pathogen, Streptococcus suis. These neuroinvasive pathogens represent common themes of host–pathogen interactions, such as colonization and invasion of mucosal barriers, survival in the blood stream, entry into the central nervous system by translocation of the blood–brain and blood–cerebrospinal fluid barrier, and induction of meningeal inflammation, affecting pia mater, the arachnoid and subarachnoid spaces.