Fachbereich Veterinärmedizin



    Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases (2017)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    de la Fuente, José
    Antunes, Sandra
    Bonnet, Sarah
    Cabezas-Cruz, Alejandro
    Domingos, Ana G
    Estrada-Peña, Agustín
    Johnson, Nicholas
    Kocan, Katherine M
    Mansfield, Karen L
    Nijhof, Ard M (WE 13)
    Papa, Anna
    Rudenko, Nataliia
    Villar, Margarita
    Alberdi, Pilar
    Torina, Alessandra
    Ayllón, Nieves
    Vancova, Marie
    Golovchenko, Maryna
    Grubhoffer, Libor
    Caracappa, Santo
    Fooks, Anthony R
    Gortazar, Christian
    Rego, Ryan O M
    Frontiers in cellular and infection microbiology; 7 — S. 114
    ISSN: 2235-2988
    DOI: 10.3389/fcimb.2017.00114
    Pubmed: 28439499
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    +49 30 838 62310

    Abstract / Zusammenfassung

    Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.