Publikationsdatenbank

Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases (2017)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

de la Fuente, José

Antunes, Sandra

Bonnet, Sarah

Cabezas-Cruz, Alejandro

Domingos, Ana G

Estrada-Peña, Agustín

Johnson, Nicholas

Kocan, Katherine M

Mansfield, Karen L

Nijhof, Ard M (WE 13)

Papa, Anna

Rudenko, Nataliia

Villar, Margarita

Alberdi, Pilar

Torina, Alessandra

Ayllón, Nieves

Vancova, Marie

Golovchenko, Maryna

Grubhoffer, Libor

Caracappa, Santo

Fooks, Anthony R

Gortazar, Christian

Rego, Ryan O M

Quelle

Frontiers in Cellular and Infection Microbiology

Bandzählung: 7

Seiten: 114

ISSN: 2235-2988

Sprache

Englisch

Verweise

DOI: 10.3389/fcimb.2017.00114

Pubmed: 28439499

Kontakt

Institut für Parasitologie und Tropenveterinärmedizin

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 62310
parasitologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.