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    Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production (2017)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Wang, Yang
    Zhang, Rongmin
    Li, Jiyun
    Wu, Zuowei
    Yin, Wenjuan
    Schwarz, Stefan (WE 7)
    Tyrrell, Jonathan M
    Zheng, Yongjun
    Wang, Shaolin
    Shen, Zhangqi
    Liu, Zhihai
    Liu, Jianye
    Lei, Lei
    Li, Mei
    Zhang, Qidi
    Wu, Congming
    Zhang, Qijing
    Wu, Yongning
    Walsh, Timothy R
    Shen, Jianzhong
    Quelle
    Nature microbiology; 2(Artikel-Nr. 16260) — S. 1
    ISSN: 2058-5276
    Sprache
    Englisch
    Verweise
    DOI: 10.1038/nmicrobiol.2016.260
    Pubmed: 28165472
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    Institut für Mikrobiologie und Tierseuchen

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    +49 30 838 51840 / 51843
    mikrobiologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    By 2030, the global population will be 8.5 billion, placing pressure on international poultry production, of which China is a key producer(1). From April 2017, China will implement the withdrawal of colistin as a growth promoter, removing over 8,000 tonnes per year from the Chinese farming sector(2). To understand the impact of banning colistin and the epidemiology of multi-drug-resistant (MDR) Escherichia coli (using blaNDM and mcr-1 as marker genes), we sampled poultry, dogs, sewage, wild birds and flies. Here, we show that mcr-1, but not blaNDM, is prevalent in hatcheries, but blaNDM quickly contaminates flocks through dogs, flies and wild birds. We also screened samples directly for resistance genes to understand the true breadth and depth of the environmental and animal resistome. Direct sample testing for blaNDM and mcr-1 in hatcheries, commercial farms, a slaughterhouse and supermarkets revealed considerably higher levels of positive samples than the blaNDM- and mcr-1-positive E. coli, indicating a substantial segment of unseen resistome-a phenomenon we have termed the 'phantom resistome'. Whole-genome sequencing identified common blaNDM-positive E. coli shared among farms, flies, dogs and farmers, providing direct evidence of carbapenem-resistant E. coli transmission and environmental contamination.