Publikationsdatenbank

Lipid-based Nutrient Supplements Do Not Affect Gut Bifidobacterium Microbiota in Malawian Infants: a Randomised Trial (2016)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Aakko, Juhani

Grześkowiak, Łukasz (WE 4)

Asukas, Tiia

Päivänsäde, Eerika

Lehto, Kirsi-Maarit

Fan, Yue-Mei

Mangani, Charles

Maleta, Kenneth

Ashorn, Per

Salminen, Seppo

Quelle

Journal of pediatric gastroenterology and nutrition : JPGN; 64(4) — S. 610–615

ISSN: 0277-2116

Sprache

Englisch

Verweise

URL (Volltext): http://insights.ovid.com/crossref?an=00005176-201704000-00029

DOI: 10.1097/MPG.0000000000001333

Pubmed: 27403608

Kontakt

Institut für Tierernährung

Königin-Luise-Str. 49
Gebäude 8
14195 Berlin
+49 30 838 52256
tierernaehrung@vetmed.fu-berlin.de

Abstract / Zusammenfassung

To assess the effect of nutritional supplementation with lipid-based nutrient supplements (LNS) and corn-soy blend (CSB) flour on Bifidobacterium and Staphylococcus aureus gut microbiota composition in Malawian infants. In addition, the microbiota changes over time were characterized in the study infants.

Healthy six-month-old Malawian infants were randomly assigned to one of four intervention schemes for a six-month period. Infants in the control group were not provided with any supplementary food. Infants in other three groups received either micronutrient-fortified CSB, micronutrient-fortified LNS with milk protein base or micronutrient-fortified LNS with soy protein base between six and twelve months of age. Fecal bifidobacteria and Staphylococcus aureus gut microbiota at six and twelve months of age was analyzed by qPCR method.

There was no difference in change in bacterial prevalence or counts between the intervention groups over the 6-month study period. When looking at the total study population, higher counts of total bacteria (p = 0.028), Bifidobacterium genus (p = 0.027), B. catenulatum (p = 0.031) and lower counts of B. infantis (p < 0.001), B. lactis (p < 0.001), B. longum (p < 0.001) and S. aureus (p < 0.001) were detected in the children's stools at 12 months rather than at 6 months of age.

The dietary supplementation did not have an impact on the Bifidobacterium and Staphylococcus aureus microbiota composition of the study infants. However, the fecal bifidobacterial diversity of the infants changed towards a more adult-like microbiota profile within the observed time.