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Background: The reticuloendotheliosis virus (REV) in chicken induces a variety of deleterious effects, tumors and increased mortalities causing considerable economic losses. In this study the reticuloendotheliosis infection status were performed through antibody determination and histopathological findings in chickens in delta Egypt. Materials and Methods: Fourteen cross-bred chicken flocks varied from 12-25 weeks age and reared in two provinces in delta Egypt were investigated. About 691 birds were submitted for pathological investigations. Two hundred and seventy one serum samples were collected for serology. Further 20 samples from seropositive and seronegative birds were used for hematological screening. Results: In total of 691 birds 278 birds (40.2%) unusual tumor formation in the head and neck regions and enlarged liver, spleen and kidneys. The features of common pathologic lesions were shown as multiple neoplastic nodules of homogeneous lymphocytes in the livers and spleens. Histopathology of the head region revealed hypercellularity with intercellular transudate, focal aggregation of inflammatory cells around the diluted blood vessels and hemorrhages in tumor mass. Visceral lymphomas occurred in a 25 weeks old chicken flock. The serological prevalence for the REV antibody ranged from 25.0-100.0% at 12th and 25th weeks of age, respectively. The total WBCs, heterophils and monocytes count were significant higher in birds with tumor. Conclusion: The present study describes the first report for prevalence of REV in cross-bred chicken in delta region in Egypt. The serological results suggested circulation of REV within chicken in delta Egypt. Further study is paramount for improving the control measures for REV in chickens.