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    Procalcitonin-A Useful Biomarker for Pneumonia Associated with Rhodococcus equi? (2016)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Barton, Ann Kristin (WE 17)
    Rieger, M.
    Teschner, D.
    Gehlen, Heidrun (WE 17)
    Quelle
    Modern Research in Inflammation; 5 — S. 13–19
    ISSN: 2169-9682
    Sprache
    Englisch
    Verweise
    URL (Volltext): http://file.scirp.org/pdf/MRI_2016051116101163.pdf
    DOI: 10.4236/mri.2016.52002
    Kontakt
    Klinik für Pferde, allgemeine Chirurgie und Radiologie

    Oertzenweg 19 b
    14163 Berlin
    Tel.+49 30 838 62299 Fax.+49 30 838 62529
    email:pferdeklinik@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Background: Procalcitonin, a precursor protein of the hormone calcitonin, is a sensitive marker for sepsis in human medicine, which is used for diagnosis of bacterial pneumonia in adults and neonates to initiate antibiotic therapy. Objectives: In this study, procalcitonin was evaluated as a potential biomarker for Rhodococcus equi associated pneumonia. Methods: In four foals procalcitonin was measured at four time-points (day 0 before antibiotic therapy, day 1, 3 and 5/6 during therapy) in plasma using an equine specific ELISA. Inclusion criteria for the study were a positive sepsis score, ultrasonographic evidence of pulmonary abscesses in addition >8 cm, a positive microbiology out of tracheobronchial secretion and positive response to antibiotic treatment (azithromycin 10 mg/kg BDW 24q PO and rifampicin 10 mg/kg BDW 12q PO) within a weak including improvement of clinical status and reduction of ultrasonographic score <8 cm. Results: Procalcitonin concentrations remained below the working range of the ELISA (25 - 1000 ng/ml) in all but one sample. Conclusions: Procalcitonin cannot be regarded a useful biomarker in pneumonia associated with Rhodococcus equi.