Publikationsdatenbank

Beta-hemolytic Streptococcus dysgalactiae strains isolated from horses are a genetically distinct population within the Streptococcus dysgalactiae taxon (2016)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Pinho, Marcos D

Erol, Erdal

Ribeiro-Gonçalves, Bruno

Mendes, Catarina I

Carriço, João A

Matos, Sandra C

Preziuso, Silvia

Luebke-Becker, Antina (WE 7)

Wieler, Lothar H

Melo-Cristino, Jose

Ramirez, Mario

Quelle

Scientific reports; 6 — S. 31736

ISSN: 2045-2322

Sprache

Englisch

Verweise

DOI: 10.1038/srep31736

Pubmed: 27530432

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
Gebäude 35
14163 Berlin
+49 30 838 51840 / 51843
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The pathogenic role of beta-hemolytic Streptococcus dysgalactiae in the equine host is increasingly recognized. A collection of 108 Lancefield group C (n = 96) or L (n = 12) horse isolates recovered in the United States and in three European countries presented multilocus sequence typing (MLST) alleles, sequence types and emm types (only 56% of the isolates could be emm typed) that were, with few exceptions, distinct from those previously found in human Streptococcus dysgalactiae subsp. equisimilis. Characterization of a subset of horse isolates by multilocus sequence analysis (MLSA) and 16S rRNA gene sequence showed that most equine isolates could also be differentiated from S. dysgalactiae strains from other animal species, supporting the existence of a horse specific genomovar. Draft genome information confirms the distinctiveness of the horse genomovar and indicates the presence of potentially horse-specific virulence factors. While this genomovar represents most of the isolates recovered from horses, a smaller MLST and MLSA defined sub-population seems to be able to cause infections in horses, other animals and humans, indicating that transmission between hosts of strains belonging to this group may occur.