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    High genetic structuring of Tula hantavirus (2016)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Schmidt, Sabrina
    Saxenhofer, Moritz
    Drewes, Stephan
    Schlegel, Mathias
    Wanka, Konrad M
    Frank, Raphael
    Klimpel, Sven
    von Blanckenhagen, Felix
    Maaz, Denny (WE 13)
    Herden, Christiane
    Freise, Jona
    Wolf, Ronny
    Stubbe, Michael
    Borkenhagen, Peter
    Ansorge, Hermann
    Eccard, Jana A
    Lang, Johannes
    Jourdain, Elsa
    Jacob, Jens
    Marianneau, Philippe
    Heckel, Gerald
    Ulrich, Rainer G
    Quelle
    Archives of virology; 161(5) — S. 1135–1149
    ISSN: 0304-8608
    Verweise
    DOI: 10.1007/s00705-016-2762-6
    Pubmed: 26831932
    Kontakt
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    +49 30 838 62310
    parasitologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Tula virus (TULV) is a vole-associated hantavirus with low or no pathogenicity to humans. In the present study, 686 common voles (Microtus arvalis), 249 field voles (Microtus agrestis) and 30 water voles (Arvicola spec.) were collected at 79 sites in Germany, Luxembourg and France and screened by RT-PCR and TULV-IgG ELISA. TULV-specific RNA and/or antibodies were detected at 43 of the sites, demonstrating a geographically widespread distribution of the virus in the studied area. The TULV prevalence in common voles (16.7 %) was higher than that in field voles (9.2 %) and water voles (10.0 %). Time series data at ten trapping sites showed evidence of a lasting presence of TULV RNA within common vole populations for up to 34 months, although usually at low prevalence. Phylogenetic analysis demonstrated a strong genetic structuring of TULV sequences according to geography and independent of the rodent species, confirming the common vole as the preferential host, with spillover infections to co-occurring field and water voles. TULV phylogenetic clades showed a general association with evolutionary lineages in the common vole as assessed by mitochondrial DNA sequences on a large geographical scale, but with local-scale discrepancies in the contact areas.