Publication Database

Increased adult neurogenesis in mice with a permanent overexpression of the postsynaptic 5-HT1A receptor (2016)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Noto, Bettina (WE 14)

Klempin, Friederike

Alenina, Natalia

Bader, Michael

Fink, Heidrun (WE 14)

Sander, Svenja E (WE 14)

Quelle

Neuroscience Letters

Bandzählung: 633

Seiten: 246 – 251

ISSN: 0304-3940

Sprache

Englisch

Verweise

URL (Volltext): http://www.sciencedirect.com/science/article/pii/S0304394016306838

DOI: 10.1016/j.neulet.2016.09.051

Pubmed: 27693660

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Depression is among the leading causes of disability and disease burden. Recent studies point to an involvement of altered serotonin1A receptor (5-HT1AR) -mediated adult neurogenesis in depression. However, the exact underlying mechanisms remain unclear, mainly due to the complexity of the serotonergic system with its various receptors and their locations. Mice with permanent overexpression of postsynaptic 5-HT1ARs (OE mice) represent a unique tool for investigating the involvement of postsynaptic 5-HT1ARs in this context. Correct 5-HT1AR coupling and functioning has been demonstrated earlier, indicating that more postsynaptic 5-HT1ARs can be activated in these mice. Initially we examined morphometric parameters of the dentate gyrus (DG) and the prefrontal cortex as they are involved in adult hippocampal neurogenesis and/or depression. The volume of the DG in OE mice was increased in comparison to wildtype controls. We therefore investigated parameters of adult neurogenesis by the bromodeoxyuridine method. Proliferation and survival of newborn cells in the DG of OE mice were significantly increased. Significant increases in survived neurons were only detected in the female but not in the male subgroup. Additional staining for early precursor cells (Sox2) and progenitor cells of the neuronal lineage (doublecortin) showed an increase in type-1/2a as well as in type-2b/3 cells in OE mice. Our study suggests a leading role of the postsynaptic 5-HT1AR in adult hippocampal neurogenesis and might open an important link to depression.