Publikationsdatenbank

The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells (2016)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Schuijs, Martijn J.

Hartmann, Susanne (WE 6)

Selkirk, Murray E.

Roberts, Luke B.

Openshaw, Peter J. M.

Schnoeller, Corinna

Quelle

PLOS ONE

Bandzählung: 11

Heftzählung: 8

Seiten: e0161885

ISSN: 1932-6203

Sprache

Englisch

Verweise

URL (Volltext): http://dx.doi.org/10.1371/journal.pone.0161885

DOI: 10.1371/journal.pone.0161885

Pubmed: 27560829

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
Gebäude 35
14163 Berlin
+49 30 838 51834

Abstract / Zusammenfassung

Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may alter host immune responses to both helminths and to unrelated immune triggers. For example, we have previously shown that filarial cystatin (AvCystatin/Av17) ameliorates allergic airway inflammation. However, helminthic immunomodulators have so far not been tested in virus-induced disease. We now report that AvCystatin prevents Th2-based immunopathology in vaccine-enhanced RSV lung inflammation, a murine model for bronchiolitis. AvCystatin ablated eosinophil influx, reducing both weight loss and neutrophil recruitment without impairing anti-viral immune responses. AvCystatin also protected mice from excessive inflammation following primary RSV infection, significantly reducing neutrophil influx and cytokine production in the airways. Interestingly, we found that AvCystatin induced an influx of CD4+ FoxP3+ interleukin-10-producing T cells in the airway and lungs, correlating with immunoprotection, and the corresponding cells could also be induced by adoptive transfer of AvCystatin-primed F4/80+ macrophages. Thus, AvCystatin ameliorates enhanced RSV pathology without increasing susceptibility to, or persistence of, viral infection and warrants further investigation as a possible therapy for virus-induced airway disease.