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    Cutaneous Form of Maculopapular Mastocytosis in a Foal (2016)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Junginger, Johannes
    Geburek, Florian
    Muhammad, Akram Kahn
    Müller, Gundi
    Gruber, Achim Dieter (WE 12)
    Hewicker-Trautwein, Marion
    Quelle
    Veterinary dermatology; 27(3) — S. 202–206
    ISSN: 0959-4493
    Sprache
    Englisch
    Verweise
    URL (Volltext): http://onlinelibrary.wiley.com/doi/10.1111/vde.12308/epdf
    DOI: 10.1111/vde.12308
    Kontakt
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    +49 30 838 62450

    Abstract / Zusammenfassung

    Background

    Cutaneous mastocytosis is a rare benign disease occurring in domestic animals and humans. In previous reports, dermal findings in foals were accompanied by systemic mast cell infiltrations, whereas lesions in human cutaneous mastocytosis, including urticaria pigmentosa and solitary mastocytoma, are usually restricted to the skin.
    Objectives

    To describe a new variant of equine cutaneous maculopapular mastocytosis lacking systemic involvement.
    Animals

    A 2.5-month-old warmblood foal with multiple skin nodules since birth.
    Methods

    Clinical examination (including haematology, fine needle biopsy and thoracic radiographs), postmortem examination, histopathology and immunohistochemistry.
    Results

    Clinical examination showed 41 skin nodules that contained numerous mast cells as detected by cytology. Macroscopic examination at postmortem examination revealed intradermal circumscribed lesions ranging from 2 to 5 cm in diameter. Histologically, they were composed of well differentiated mast cells with metachromatic granules stained with toluidine blue accompanied by many eosinophils. Immunohistochemically, mast cells had mast cell growth factor receptor c-KIT predominating at the cell surface and intracytoplasmic expression of tryptase. In other organs similar mast cell infiltrations were not detected.
    Conclusions and clinical importance

    The case presented here fulfils the criteria of equine cutaneous maculopapular mastocytosis (ECMM), representing a rare entity in foals that is reported to be associated with spontaneous regression, although the long-term prognosis is not known. Unlike in previous reports, lesions described here were restricted to the skin. This may imply that ECMM is primarily a dermal disease sharing similarities with urticaria pigmentosa in young children.