Publikationsdatenbank

Cutaneous Form of Maculopapular Mastocytosis in a Foal (2016)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Junginger, Johannes

Geburek, Florian

Muhammad, Akram Kahn

Müller, Gundi

Gruber, Achim Dieter (WE 12)

Hewicker-Trautwein, Marion

Quelle

Veterinary dermatology : an international journal

Bandzählung: 27

Heftzählung: 3

Seiten: 202 – 206

ISSN: 0959-4493

Sprache

Englisch

Verweise

URL (Volltext): http://onlinelibrary.wiley.com/doi/10.1111/vde.12308/epdf

DOI: 10.1111/vde.12308

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background

Cutaneous mastocytosis is a rare benign disease occurring in domestic animals and humans. In previous reports, dermal findings in foals were accompanied by systemic mast cell infiltrations, whereas lesions in human cutaneous mastocytosis, including urticaria pigmentosa and solitary mastocytoma, are usually restricted to the skin.
Objectives

To describe a new variant of equine cutaneous maculopapular mastocytosis lacking systemic involvement.
Animals

A 2.5-month-old warmblood foal with multiple skin nodules since birth.
Methods

Clinical examination (including haematology, fine needle biopsy and thoracic radiographs), postmortem examination, histopathology and immunohistochemistry.
Results

Clinical examination showed 41 skin nodules that contained numerous mast cells as detected by cytology. Macroscopic examination at postmortem examination revealed intradermal circumscribed lesions ranging from 2 to 5 cm in diameter. Histologically, they were composed of well differentiated mast cells with metachromatic granules stained with toluidine blue accompanied by many eosinophils. Immunohistochemically, mast cells had mast cell growth factor receptor c-KIT predominating at the cell surface and intracytoplasmic expression of tryptase. In other organs similar mast cell infiltrations were not detected.
Conclusions and clinical importance

The case presented here fulfils the criteria of equine cutaneous maculopapular mastocytosis (ECMM), representing a rare entity in foals that is reported to be associated with spontaneous regression, although the long-term prognosis is not known. Unlike in previous reports, lesions described here were restricted to the skin. This may imply that ECMM is primarily a dermal disease sharing similarities with urticaria pigmentosa in young children.