Fachbereich Veterinärmedizin


Service-Navigation

    Publikationsdatenbank

    Circulation of clonal populations of fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST410 in humans and animals in Germany (2016)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Falgenhauer, Linda
    Imirzalioglu, Can
    Ghosh, Hiren
    Gwozdzinski, Konrad
    Schmiedel, Judith
    Gentil, Katrin
    Bauerfeind, Rolf
    Kämpfer, Peter
    Seifert, Harald
    Michael, Geovana Brenner
    Schwarz, Stefan
    Pfeifer, Yvonne
    Werner, Guido
    Pietsch, Michael
    Guerra, Beatriz
    Fischer, Jennie
    Sharp, Hannah
    Käsbohrer, Annemarie
    Goesmann, Alexander
    Hille, Katja
    Kreienbrock, Lothar
    Chakraborty, Trinad
    Rösler, Uwe (WE 10)
    Quelle
    International journal of antimicrobial agents; 47(6) — S. 457–465
    ISSN: 0924-8579
    Sprache
    Englisch
    Verweise
    DOI: 10.1016/j.ijantimicag.2016.03.019
    Pubmed: 27208899
    Kontakt
    Institut für Tier- und Umwelthygiene

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14169 Berlin
    Tel.+49 30 8385 1845 Fax.+49 30 83845 1863
    email:tierhygiene@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Multidrug-resistant Escherichia coli encoding CTX-M-type extended-spectrum β-lactamases (ESBLs) are isolated in increasing numbers from humans, companion animals and livestock, raising concern regarding the exchange and spread of isolates in these populations. In this study, whole-genome sequencing of CTX-M-15-producing E. coli isolates recently sampled from humans, companion animals, livestock and farm environments was performed. In total, 26 different sequence types (STs) were detected, of which ST410 was the most frequent and was the only ST present in all populations studied. Five clades (designated A-E) were detected within the ST410 isolates. In particular, isolates of clade B were present in all four populations and had core genomes that differed by less than 70 single nucleotide polymorphisms (SNPs). Isolates of clades B and C were also clonally marked, exhibiting identical chromosomal insertions of blaCTX-M-15 at distinct loci. These data provide strong evidence for the clonal dissemination of specific clades of CTX-M-15-producing E. coli ST410 in human and animal populations.