Fachbereich Veterinärmedizin



    Clonal spread and interspecies transmission of clinically relevant ESBL-producing Escherichia coli of ST410--another successful pandemic clone? (2016)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Schaufler, Katharina (WE 7)
    Semmler, Torsten
    Wieler, Lothar H
    Wöhrmann, Michael
    Baddam, Ramani
    Ahmed, Niyaz
    Müller, Kerstin
    Kola, Axel
    Fruth, Angelika
    Ewers, Christa
    Guenther, Sebastian (WE 7)
    FEMS microbiology ecology; 92(1) — S. 1–9
    ISSN: 0168-6496
    DOI: 10.1093/femsec/fiv155
    Pubmed: 26656065
    Institut für Mikrobiologie und Tierseuchen

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    Abstract / Zusammenfassung

    Clinically relevant extended-spectrum beta-lactamase (ESBL)-producing multi-resistant Escherichia coli have been on the rise for years. Initially restricted to mostly a clinical context, recent findings prove their prevalence in extraclinical settings independent of the original occurrence of antimicrobial resistance in the environment. To get further insights into the complex ecology of potentially clinically relevant ESBL-producing E. coli, 24 isolates from wild birds in Berlin, Germany, and 40 ESBL-producing human clinical E. coli isolates were comparatively analyzed. Isolates of ST410 occurred in both sample groups (six). In addition, three ESBL-producing E. coli isolates of ST410 from environmental dog feces and one clinical dog isolate were included. All 10 isolates were clonally analyzed showing almost identical macrorestriction patterns. They were chosen for whole-genome sequencing revealing that the whole-genome content of these 10 E. coli isolates showed a very high genetic similarity, differing by low numbers of single nucleotide polymorphisms only. This study gives initial evidence for a recent interspecies transmission of a new successful clone of ST410 E. coli between wildlife, humans, companion animals and the environment. The results underline the zoonotic potential of clinically relevant multi-resistant bacteria found in the environment as well as the mandatory nature of the 'One Health' approach.