Fachbereich Veterinärmedizin



    Evidence-based review of efficacy and adverse effects of joint medication and evaluation of synovial fluid and serum markers for osteoarthritis in the horse (2015)

    Ehrle, Anna (WE 17)
    — 82 Seiten
    URL (Volltext): http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000101658
    Klinik für Pferde, allgemeine Chirurgie und Radiologie

    Oertzenweg 19 b
    14163 Berlin
    +49 30 838 62299

    Abstract / Zusammenfassung

    Osteoarthritis (OA) continues to be one of the most common causes of equine lameness. Although several therapeutic approaches have been shown to be beneficial in the treatment of OA, intra-articular medication remains one of the most effective treatment options. Since OA and its successful treatment is the subject of intensive ongoing research a vast quantity of scientific data regarding effectiveness, dosage and mechanism of action for joint medications is available.
    Evidence-based medicine is the judicious use of the current best available scientific research in making decisions about the care of individual patients. The practice of evidence-based medicine means integrating one’s individual clinical expertise with the best available external clinical evidence from systematic research. Communicating evidence-based information about a clinical condition and the treatment options available helps the owner to make informed decisions about their animal.
    Based on a systematic review of the current literature, relevant information about commonly used intra-articular joint medications as well as regenerative and innovative medications was summarised. Joint medication was shown to be a low-risk procedure when performed according to the standards of good veterinary practice.
    Further the concentration of interleukin-1 repector antagonist (IL-1Ra) and IL-1β was determined in the synovial fluid (SF) and serum (SE) of horses with different grades of joint disease using equine specific ELISA systems. The concentration of IL-Ra in SF and IL-1β in SE appear to reflect the severity of intra-synovial inflammation. Modern equine specific ELISA tests have improved our capability to detect levels of biochemical parameters in SF and SE of horses with clinical joint disease. IL-1Ra in SF in combination with further biomarkers might be useful to assess the extent of intra-synovial inflammation. These results require a larger number of clinical cases to be utilized in order to confirm the benefit of using the equine specific ELISA. There remains a great deal of further experimentation to be undertaken to develop a testing system, which will reliably indicate the severity of joint disease in the horse.