Fachbereich Veterinärmedizin



    Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach (2015)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Grosenick, Dirk
    Cantow, Kathleen
    Arakelyan, Karen
    Wabnitz, Heidrun
    Flemming, Bert
    Skalweit, Angela
    Ladwig, Mechthild (WE 11)
    Macdonald, Rainer
    Niendorf, Thoralf
    Seeliger, Erdmann
    Biomedical optics express; 6(2) — S. 309–323
    ISSN: 2156-7085
    DOI: 10.1364/BOE.6.000309
    Pubmed: 25780726
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    Abstract / Zusammenfassung

    We hypothesize that combining quantitative near-infrared spectroscopy (NIRS) with established invasive techniques will enable advanced insights into renal hemodynamics and oxygenation in small animal models. We developed a NIRS technique to monitor absolute values of oxygenated and deoxygenated hemoglobin and of oxygen saturation of hemoglobin within the renal cortex of rats. This NIRS technique was combined with invasive methods to simultaneously record renal tissue oxygen tension and perfusion. The results of test procedures including occlusions of the aorta or the renal vein, hyperoxia, hypoxia, and hypercapnia demonstrated that the combined approach, by providing different but complementary information, enables a more comprehensive characterization of renal hemodynamics and oxygenation.