Fachbereich Veterinärmedizin



    Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells (2016)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Claessen, Christophe
    De Lange, Valérie
    Huang, Teng (WE 5)
    Ma, Guanggang (WE 5)
    Osterrieder, Nikolaus (WE 5)
    Favoreel, Herman
    Van de Walle, Gerlinde R
    The veterinary journal; 210(April) — S. 85–88
    ISSN: 0372-5545
    DOI: 10.1016/j.tvjl.2015.12.008
    Pubmed: 26920348
    Institut für Virologie

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    +49 30 838 51833

    Abstract / Zusammenfassung

    Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.