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    Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy (2015)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Equilino, Mirjam
    Théodoloz, Vincent
    Gorgas, Daniela
    Doherr, Marcus G. (WE 16)
    Heilmann, Romy M.
    Suchodolski, Jan S.
    Steiner, Jörg M.
    Burgener, Iwan A.
    Quelle
    Journal of the American Veterinary Medical Association; 246(1) — S. 91–99
    ISSN: 0003-1488
    Sprache
    Englisch
    Verweise
    DOI: 10.2460/javma.246.1.91
    Pubmed: 25517330
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    Institut für Veterinär-Epidemiologie und Biometrie

    Königsweg 67
    Gebäude 21, 1. OG
    14163 Berlin
    Tel.: +49 30 838 62901 (Sekretariat)
    Fax: +49 (30) 838 4 71714

    Abstract / Zusammenfassung

    To evaluate serum concentrations of biochemical markers and survival time in dogs with protein-losing enteropathy (PLE).

    Prospective study.

    29 dogs with PLE and 18 dogs with food-responsive diarrhea (FRD).

    Data regarding serum concentrations of various biochemical markers at the initial evaluation were available for 18 of the 29 dogs with PLE and compared with findings for dogs with FRD. Correlations between biochemical marker concentrations and survival time (interval between time of initial evaluation and death or euthanasia) for dogs with PLE were evaluated.

    Serum C-reactive protein concentration was high in 13 of 18 dogs with PLE and in 2 of 18 dogs with FRD. Serum concentration of canine pancreatic lipase immunoreactivity was high in 3 dogs with PLE but within the reference interval in all dogs with FRD. Serum α1-proteinase inhibitor concentration was less than the lower reference limit in 9 dogs with PLE and 1 dog with FRD. Compared with findings in dogs with FRD, values of those 3 variables in dogs with PLE were significantly different. Serum calprotectin (measured by radioimmunoassay and ELISA) and S100A12 concentrations were high but did not differ significantly between groups. Seventeen of the 29 dogs with PLE were euthanized owing to this disease; median survival time was 67 days (range, 2 to 2,551 days).

    Serum C-reactive protein, canine pancreatic lipase immunoreactivity, and α1-proteinase inhibitor concentrations differed significantly between dogs with PLE and FRD. Most initial biomarker concentrations were not predictive of survival time in dogs with PLE.