Fachbereich Veterinärmedizin



    Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias (2016)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Kunec, Dusan (WE 5)
    Osterrieder, Nikolaus (WE 5)
    Cell reports; 14(1) — S. 55–67
    ISSN: 2211-1247
    URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000023845
    DOI: 10.1016/j.celrep.2015.12.011
    Pubmed: 26725119
    Institut für Virologie

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35
    14163 Berlin
    +49 30 838 51833

    Abstract / Zusammenfassung

    Codon pair bias is a remarkably stable characteristic of a species. Although functionally uncharacterized, robust virus attenuation was achieved by recoding of viral proteins using underrepresented codon pairs. Because viruses replicate exclusively inside living cells, we posited that their codon pair preferences reflect those of their host(s). Analysis of many human viruses showed, however, that the encoding of viruses is influenced only marginally by host codon pair preferences. Furthermore, examination of codon pair preferences of vertebrate, insect, and arthropod-borne viruses revealed that the latter do not utilize codon pairs overrepresented in arthropods more frequently than other viruses. We found, however, that codon pair bias is a direct consequence of dinucleotide bias. We conclude that codon pair bias does not play a major role in the encoding of viral proteins and that virus attenuation by codon pair deoptimization has the same molecular underpinnings as attenuation based on an increase in CpG/TpA dinucleotides.