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Foot and Mouth Disease (FMD) is a highly contagious disease that can cause considerable economic losses to the cattle and buffalo farmers. This study was aimed to identify the potential risk factors of FMD in the Anuradhapura district, Sri Lanka. Four divisional secretariat areas were selected from Anuradhapura district based on FMD disease prevalence.
Twenty case farms and forty control farms were selected from eacharea. A Questionnaire was used to collect the information with regard to the risk factors of FMD. Odds ratios (OR) and 95% confidenceintervals (95% CI) were calculated to determine association between potential risk factors with reference to case and control farms. The results showed that feeding animals with cut and fed method (OR=3.06, 95% CI=1.53,6.39 ), animal contact that occurs grazing near the lake areas (OR= 2.35, 95% CI=1.22,4.68), animal contact that occurs at the village level (OR= 2.92, 95% CI=1.41,6.41), animal contact that occurs between villages (OR= 1.82, 95% CI=1.02,3.3), and purchasing or selling animal during the outbreak (OR= 2.13, 95% CI=1.17,3.36) were the risk factors associated with the recent FMD outbreak. Findings from this study are expected to contribute towards priority setting and implementation of disease control measures for FMD.