Fachbereich Veterinärmedizin



    IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites (2016)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Wadwa, M
    Klopfleisch, R (WE 12)
    Adamczyk, A
    Frede, A
    Pastille, E
    Mahnke, K
    Hansen, W
    Geffers, R
    Lang, K S
    Buer, J
    Büning, J
    Westendorf, A M
    Mucosal immunology; 9 — S. 1263–1277
    ISSN: 1933-0219
    DOI: 10.1038/mi.2015.132
    Pubmed: 26732675
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
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    Abstract / Zusammenfassung

    Inflammatory bowel disease (IBD) is characterized by chronic, uncontrolled inflammation in the intestinal mucosa. Although the etiology is poorly understood, it is widely accepted that loss of tolerance is involved in the development of IBD. Therefore, re-establishing tolerance or gut homeostasis is one of the key features in the development of new therapeutic strategies. Here we show that antigen targeting to DEC-205 on dendritic cells leads to an interleukin (IL)-10-dependent downregulation of C-X-C chemokine receptor 3 (CXCR3) expression on differentiated antigen-specific T helper type 1 (Th1) cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation. Moreover, CD4(+)CXCR3(+) T cells are highly enriched in the inflamed mucosa of IBD patients. Interference with this pathway may therefore be a promising approach for the treatment of IBD. In conclusion, we propose a hitherto undescribed mechanism by which IL-10 can act on effector T cells and orchestrate intestinal immune responses.Mucosal Immunology advance online publication 6 January 2016. doi:10.1038/mi.2015.132.