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    Actinobacillus Pleuropneumoniae Serotype 7 Siderophore Receptor FhuA is Not Required for Virulence (2003)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Baltes, Nina
    Tonpitak, Walaiporn
    Hennig-Pauka, Isabel
    Gruber, Achim D (WE 12)
    Gerlach, Gerald F
    Quelle
    FEMS microbiology letters; 220(1) — S. 41–48
    ISSN: 0378-1097
    Sprache
    Englisch
    Verweise
    Pubmed: 12644226
    Kontakt
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    Tel.+49 30 838 62450 Fax.+49 30 838 62522

    Abstract / Zusammenfassung

    A ferrichrome receptor, FhuA, was identified in Actinobacillus pleuropneumoniae serotype 7. An isogenic mutant with a deletion in the ferrichrome uptake receptor gene (fhuA) was constructed and examined in an aerosol infection model. The disease caused by the mutant was indistinguishable from disease induced by A. pleuropneumoniae serotype 7 wild-type; an isogenic mutant lacking expression of the exbB gene that is required for the uptake of transferrin-bound iron retained the ability to utilize ferrichrome, thereby indicating that an energy-coupling mechanism involved in ferrichrome transport remains to be identified.