Publikationsdatenbank

Actinobacillus Pleuropneumoniae Serotype 7 Siderophore Receptor FhuA is Not Required for Virulence (2003)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Baltes, Nina

Tonpitak, Walaiporn

Hennig-Pauka, Isabel

Gruber, Achim D (WE 12)

Gerlach, Gerald F

Quelle

FEMS microbiology letters

Bandzählung: 220

Heftzählung: 1

Seiten: 41 – 48

ISSN: 0378-1097

Sprache

Englisch

Verweise

Pubmed: 12644226

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
Gebäude 12
14163 Berlin
+49 30 838 62450

Abstract / Zusammenfassung

A ferrichrome receptor, FhuA, was identified in Actinobacillus pleuropneumoniae serotype 7. An isogenic mutant with a deletion in the ferrichrome uptake receptor gene (fhuA) was constructed and examined in an aerosol infection model. The disease caused by the mutant was indistinguishable from disease induced by A. pleuropneumoniae serotype 7 wild-type; an isogenic mutant lacking expression of the exbB gene that is required for the uptake of transferrin-bound iron retained the ability to utilize ferrichrome, thereby indicating that an energy-coupling mechanism involved in ferrichrome transport remains to be identified.