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    Clustering of the Human CLCA Gene Family on the Short Arm of Chromosome 1 (1p22-31) (1999)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Gruber, A D (WE 12)
    Pauli, B U
    Quelle
    Genome / National Research Council Canada = Génome / Conseil national de recherches Canada; 42(5) — S. 1030–1032
    ISSN: 0831-2796
    Sprache
    Englisch
    Verweise
    Pubmed: 10584316
    Kontakt
    Institut für Tierpathologie

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    Gebäude 12
    14163 Berlin
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    Abstract / Zusammenfassung

    The CLCA gene family is a novel family of calcium-activated chloride channels. Several family members have recently been cloned from different mammalian species with distinct, highly tissue-specific expression patterns. Here, we describe radiation hybrid mapping of the human CLCA2 and CLCA3 genes using the Genebridge 4 panel. Both genes were mapped to adjacent loci on the short arm of chromosome 1 (1p22-31), a region to which the human CLCA1 had been assigned earlier. The results show clustering of all human CLCA family members known so far despite their moderately low levels of sequence homology and their heterogeneous expression patterns.