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    Tumorigenicity of Human Breast Cancer is associated with Loss of the Ca2+-activated Chloride Channel CLCA2 (1999)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Gruber, A D (WE 12)
    Pauli, B U
    Quelle
    Cancer research; 59(21) — S. 5488–5491
    ISSN: 0008-5472
    Sprache
    Englisch
    Verweise
    Pubmed: 10554024
    Kontakt
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    Tel.+49 30 838 62450 Fax.+49 30 838 62522

    Abstract / Zusammenfassung

    The human Ca2+-activated chloride channel-2 (CLCA2) is expressed in normal breast epithelium but not in breast tumors of different stages of progression. Northern analysis of nontransformed and transformed breast epithelial cell lines revealed CLCA2 expression in the nontransformed cell line MCF10A and the nontumorigenic cell line MDA-MB-453, whereas all tumorigenic cell lines were negative (MDA-MB-231, MDA-MB-435, MDA-MB-468, and MCF7). When stably reintroduced into CLCA2-negative MDA-MB-231 and MDA-MB-435 cells, CLCA2 expression reduced Matrigel invasion in vitro and inducibility of s.c. and metastatic tumors of MDA-MB-231 cells in nude mice. Our results suggest that CLCA2 may act as a tumor suppressor in breast cancer.