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Chronic diarrhea occurs frequently in dogs and common causes include intestinal lymphoma (IL) or inflammatory enteropathies, including food-responsive (FRE), antibiotic-responsive (ARE), or steroid-responsive enteropathy (SRE). The objective of this study was to compare characteristics and blood parameters of dogs with these conditions. Medical records of 102 dogs with chronic diarrhea and a diagnosis of FRE (64), ARE (11), SRE (22), or IL (5) were retrospectively reviewed (Small Animal Clinic, Freie Universitaet Berlin, 2009 to 2011). P values less than 0.05 were considered statistically significant and were based on Kruskal Wallis tests for continuous variables and Pearson chisquareor Fisher exact tests for categorical data. Dogs with IL and SRE were older (median [range in years]: IL: 9.0 [7.0-13.0], SRE: 8.0 [1.0-12.5], FRE: 5.3 [0.5-13.5], ARE: 4.0 [1.0-12.0]) and large breed dogs were overrepresented in the IL and SRE groups (IL: 4/5, SRE: 14/22, FRE: 24/64, ARE: 6/11), but there were no significant differences in age and breed size
(p = 0.076 and p = 0.061, respectively). Underweight to thin body condition was significantly associated with IL (IL: 5/5, SRE: 17/22, FRE: 33/64, ARE: 7/11; p = 0.044). The canine inflammatory bowel disease activity index was significantly increased in dogs with IL or SRE (median [range in points]: IL: 11 [5-15], SRE: 11 [4-16]; FRE: 7 [2-14], ARE: 7 [4-13]; p < 0.000). Lack of treatment response was significantly associated with IL (IL: 3/4, SRE: 6/20, FRE: 0/63, ARE: 0/11; p < 0.000). Anemia, thrombocytopenia, and increased plasma urea were significantly associated with IL (anemia: IL: 4/5, SRE: 13/22, FRE: 11/64, ARE: 5/11, p < 0.000; thrombocytopenia: IL: 3/5, SRE: 0/22, FRE: 4/64, ARE: 0/11, p = 0.004; increased urea: IL: 3/5, SRE: 1/22, FRE: 2/62, ARE: 1/11, p = 0.003). Hypoalbuminemia (<20 g/L) and hypocobalaminemia (<200 pg/mL) occurred significantly more frequently in dogs with SRE (hypoalbuminemia: IL: 0/5, SRE: 10/22, FRE: 1/62, ARE: 1/11, p < 0.000; hypocobalaminemia: IL: 0/3, SRE: 9/20, FRE: 8/63, ARE: 1/11, p = 0.015). Results of this study show that elderly and large breed dogs were more frequently affected with IL and SRE compared to other etiologies and both IL and SRE were associated with greater disease severity and/or a negative outcome. In comparison, anemia, thrombocytopenia, and increased plasma urea were most frequently detected in IL whereas severe hypoalbuminemia and hypocobalaminemia were significantly associated with SRE.