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Ineffective chemical treatments due to limited accessibility of quality trypanocides, gaps in farmers’ knowledge and technical limitations in the detection of trypanocide resistance are allowing African Animal Trypanosomosis to persist in tsetse-infested areas of sub-Saharan Africa. For these reasons, TRYRAC aims to improve trypanosomosis management of livestock smallholders in western, eastern and southern Africa. The project is funded by the European Commission for a period of 5 years (2012-2017). In a multi-disciplinary approach, trypanocide quality assessment, improved molecular resistance diagnostics and state-of-the-art disease management techniques are being developed, implemented and validated to be eventually transferred to African veterinary health facilities in Togo, Ethiopia and Mozambique. Fact finding missions to Togo and Ethiopia were conducted in autumn 2013 in order to explore the project regions. Thereby, high abundance of biting insects and ticks, illegal drug markets, high calf mortality and the farmers’ limited access to professional veterinary care were observed. Based on these findings, adapted tsetse and trypanosomosis control strategies were designed for each region that comprise 1) education packages on rational drug use of trypanocides/vermicides and on good animal husbandry and 2) establishment of demonstration sites where correct drug usage and seasonally adapted vector control will be applied and monitored. These sites will serve as demonstration plots during regularly held workshops aimed at farmers and veterinary staff. Extension messages are being disseminated by Vétérinaires sans Frontières Belgium. Close collaboration between the project partners and veterinary facilities of the respective countries is a prerequisite for sustainability. This is done by involving local universities, veterinary national agricultural research systems and community-based organisations in planning and implementing project activities. Socio-economic and biological impact assessment will be conducted by questionnaire surveys and longitudinal studies.