Fachbereich Veterinärmedizin



    Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions (2014)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Kotze, Andrew C
    Hunt, Peter W
    Skuce, Philip
    von Samson-Himmelstjerna, Georg (WE 13)
    Martin, Richard J
    Sager, Heinz
    Krücken, Jürgen (WE 13)
    Hodgkinson, Jane
    Lespine, Anne
    Jex, Aaron R
    Gilleard, John S
    Beech, Robin N
    Wolstenholme, Adrian J
    Demeler, Janina (WE 13)
    Robertson, Alan P
    Charvet, Claude L
    Neveu, Cedric
    Kaminsky, Ronald
    Rufener, Lucien
    Alberich, Melanie
    Menez, Cecile
    Prichard, Roger K
    International journal for parasitology. Drugs and drug resistance; 4(3) — S. 164–184
    ISSN: 2211-3207
    URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000021294
    DOI: 10.1016/j.ijpddr.2014.07.007
    Pubmed: 25516826
    Institut für Parasitologie und Tropenveterinärmedizin

    Robert-von-Ostertag-Str. 7-13
    Gebäude 35, 22, 23
    14163 Berlin
    +49 30 838 62310

    Abstract / Zusammenfassung

    Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS) provides a forum for scientists to meet and discuss the latest developments in the search for molecular markers of anthelmintic resistance. Such markers are important for detecting drug resistant worm populations, and indicating the likely impact of the resistance on drug efficacy. The molecular basis of resistance is also important for understanding how anthelmintics work, and how drug resistant populations arise. Changes to target receptors, drug efflux and other biological processes can be involved. This paper reports on the CARS group meeting held in August 2013 in Perth, Australia. The latest knowledge on the development of molecular markers for resistance to each of the principal classes of anthelmintics is reviewed. The molecular basis of resistance is best understood for the benzimidazole group of compounds, and we examine recent work to translate this knowledge into useful diagnostics for field use. We examine recent candidate-gene and whole-genome approaches to understanding anthelmintic resistance and identify markers. We also look at drug transporters in terms of providing both useful markers for resistance, as well as opportunities to overcome resistance through the targeting of the transporters themselves with inhibitors. Finally, we describe the tools available for the application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance.