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    Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice (2014)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Dames, Claudia
    Akyüz, Levent
    Reppe, Katrin
    Tabeling, Christoph
    Dietert, Kristina
    Kershaw, Olivia (WE 12)
    Gruber, Achim D (WE 12)
    Meisel, Christian
    Meisel, Andreas
    Witzenrath, Martin
    Engel, Odilo
    Quelle
    American journal of respiratory cell and molecular biology; 51(6) — S. 730–737
    ISSN: 1535-4989
    Sprache
    Englisch
    Verweise
    DOI: 10.1165/rcmb.2014-0052MA
    Pubmed: 24960575
    Kontakt
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    Tel.+49 30 838 62450 Fax.+49 30 838 62522

    Abstract / Zusammenfassung

    Lung diseases, including pneumonia and asthma, are among the most prevalent human disorders, and murine models have been established to investigate their pathobiology and develop novel treatment approaches. Whereas bronchoscopy is valuable for diagnostic and therapeutic procedures in patients, no equivalent for small rodents has been established. Here, we introduce a miniaturized video-bronchoscopy system offering new opportunities in experimental lung research. With an outer diameter of 0.75 mm, it is possible to advance the optics into the main bronchi of mice. An irrigation channel allows bronchoalveolar lavage and unilateral application of substances to one lung. Even a unilateral infection is possible, enabling researchers to use the contralateral lung as internal control.