Publikationsdatenbank

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Dames, Claudia

Akyüz, Levent

Reppe, Katrin

Tabeling, Christoph

Dietert, Kristina

Kershaw, Olivia (WE 12)

Gruber, Achim D (WE 12)

Meisel, Christian

Meisel, Andreas

Witzenrath, Martin

Engel, Odilo

Quelle

American journal of respiratory cell and molecular biology

Bandzählung: 51

Heftzählung: 6

Seiten: 730 – 737

ISSN: 1535-4989

Sprache

Englisch

Verweise

DOI: 10.1165/rcmb.2014-0052MA

Pubmed: 24960575

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Lung diseases, including pneumonia and asthma, are among the most prevalent human disorders, and murine models have been established to investigate their pathobiology and develop novel treatment approaches. Whereas bronchoscopy is valuable for diagnostic and therapeutic procedures in patients, no equivalent for small rodents has been established. Here, we introduce a miniaturized video-bronchoscopy system offering new opportunities in experimental lung research. With an outer diameter of 0.75 mm, it is possible to advance the optics into the main bronchi of mice. An irrigation channel allows bronchoalveolar lavage and unilateral application of substances to one lung. Even a unilateral infection is possible, enabling researchers to use the contralateral lung as internal control.