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    Thyroid transcription factor-1 is a specific marker of benign but not malignant feline lung tumours (2014)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Kujawa, A (WE 12)
    Olias, P (WE 12)
    Böttcher, A (WE 12)
    Klopfleisch, R (WE 12)
    Quelle
    Journal of Comparative Pathology; 151(1) — S. 19–24
    ISSN: 0021-9975
    Sprache
    Englisch
    Verweise
    DOI: 10.1016/j.jcpa.2014.03.004
    Pubmed: 24813152
    Kontakt
    Institut für Tierpathologie

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    Gebäude 12
    14163 Berlin
    +49 30 838 62450

    Abstract / Zusammenfassung

    Feline lung tumours are currently subclassified according to the criteria of the World Health Organisation, but this scheme contains overlap in the tumour phenotype. The aims of the present study were to re-evaluate the histological features of feline lung tumours and to correlate these with expression of the markers thyroid transcription factor (TTF)-1 and Ki67. TTF-1 was found to be a highly specific marker for neoplastic and non-neoplastic lung tissue and thyroid tissue, but was expressed only weakly in invasive lung tumours. A combined semiquantitative score for Ki67 and TTF-1 expression correlated well with differentiation and invasive behaviour of the tumours and may thus be of potential value for evaluation of feline lung tumours.