Publikationsdatenbank

Thyroid transcription factor-1 is a specific marker of benign but not malignant feline lung tumours (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kujawa, A (WE 12)

Olias, P (WE 12)

Böttcher, A (WE 12)

Klopfleisch, R (WE 12)

Quelle

Journal of comparative pathology

Bandzählung: 151

Heftzählung: 1

Seiten: 19 – 24

ISSN: 0021-9975

Sprache

Englisch

Verweise

DOI: 10.1016/j.jcpa.2014.03.004

Pubmed: 24813152

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Feline lung tumours are currently subclassified according to the criteria of the World Health Organisation, but this scheme contains overlap in the tumour phenotype. The aims of the present study were to re-evaluate the histological features of feline lung tumours and to correlate these with expression of the markers thyroid transcription factor (TTF)-1 and Ki67. TTF-1 was found to be a highly specific marker for neoplastic and non-neoplastic lung tissue and thyroid tissue, but was expressed only weakly in invasive lung tumours. A combined semiquantitative score for Ki67 and TTF-1 expression correlated well with differentiation and invasive behaviour of the tumours and may thus be of potential value for evaluation of feline lung tumours.