Publikationsdatenbank

Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies (2014)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

von Deetzen, Marie-Charlotte

Schmeck, Bernd T

Gruber, Achim D (WE 12)

Klopfleisch, Robert (WE 12)

Quelle

ISRN Veterinary Science

Bandzählung: 2014

Seiten: 148597

ISSN: 2090-4460

Sprache

Englisch

Verweise

URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000022565

DOI: 10.1155/2014/148597

Pubmed: 25002976

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

MicroRNA has been suspected to be generally involved in carcinogenesis since their first description. A first study supported this assumption for canine mammary tumors when miRNA expression was compared to normal gland. The present study extends these results by comparing the expression of 16 microRNA (miRNA) and 4 small nucleolar RNA (snoRNA) in tumors of different malignancy, for example, adenomas, nonmetastasizing and metastasizing carcinomas as well as lymph node metastases, with each other and with normal mammary gland. All neoplastic tissues differed in their miR-210 expression levels from normal gland. While metastatic cells differed in their expression of mir-29b, miR-101, mir-125a, miR-143, and miR-145 from primary tumors, the comparison of miRNA expression in primary tumors of different malignancy failed to reveal significant differences except for a significant downregulation of mir-125a in metastasizing carcinomas when compared to adenomas.