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    Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies (2014)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    von Deetzen, Marie-Charlotte
    Schmeck, Bernd T
    Gruber, Achim D (WE 12)
    Klopfleisch, Robert (WE 12)
    Quelle
    ISRN Veterinary Science
    Bandzählung: 2014
    Seiten: 148597
    ISSN: 2090-4460
    Sprache
    Englisch
    Verweise
    URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000022565
    DOI: 10.1155/2014/148597
    Pubmed: 25002976
    Kontakt
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    14163 Berlin
    +49 30 838 62450
    pathologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    MicroRNA has been suspected to be generally involved in carcinogenesis since their first description. A first study supported this assumption for canine mammary tumors when miRNA expression was compared to normal gland. The present study extends these results by comparing the expression of 16 microRNA (miRNA) and 4 small nucleolar RNA (snoRNA) in tumors of different malignancy, for example, adenomas, nonmetastasizing and metastasizing carcinomas as well as lymph node metastases, with each other and with normal mammary gland. All neoplastic tissues differed in their miR-210 expression levels from normal gland. While metastatic cells differed in their expression of mir-29b, miR-101, mir-125a, miR-143, and miR-145 from primary tumors, the comparison of miRNA expression in primary tumors of different malignancy failed to reveal significant differences except for a significant downregulation of mir-125a in metastasizing carcinomas when compared to adenomas.