Publication Database

Concentrations of Strontium, Barium, Cadmium, Copper, Zinc, Manganese, Chromium, Antimony, Selenium, and Lead in the Liver and Kidneys of Dogs According to Age, Gender, and the Occurrence of Chronic Kidney Disease (2015)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Passlack, Nadine (WE 4)

Mainzer, Barbara

Lahrssen-Wiederholt, Monika

Schafft, Helmut

Palavinskas, Richard

Breithaupt, Angele (WE 12)

Zentek, Jürgen (WE 4)

Quelle

Journal of veterinary science / The Korean Society of Veterinary Science

Bandzählung: 16

Heftzählung: 1

Seiten: 57 – 66

ISSN: 1229-845x

Sprache

Englisch

Verweise

URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000022272

Pubmed: 25234328

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

This study was conducted to measure the concentrations of strontium (Sr), barium (Ba), cadmium (Cd), copper (Cu), zinc (Zn), manganese (Mn), chromium (Cr), antimony (Sb), selenium (Se), and lead (Pb) in canine liver, renal cortex, and renal medulla, and the association of these concentrations with age, gender, and occurrence of chronic kidney disease (CKD). Tissues from 50 dogs were analyzed using inductively coupled plasma mass spectrometry. Cu, Zn, and Mn levels were highest in the liver followed by the renal cortex and renal medulla. The highest Sr, Cd, and Se concentrations were measured in the renal cortex while lower levels were found in the renal medulla and liver. Female dogs had higher tissue concentrations of Sr (liver and renal medulla), Cd (liver), Zn (liver and renal cortex), Cr (liver, renal cortex, and renal medulla), and Pb (liver) than male animals. Except for Mn and Sb, age-dependent variations were observed for all element concentrations in the canine tissues. Hepatic Cd and Cr concentrations were higher in dogs with CKD. In conclusion, the present results provide new knowledge about the storage of specific elements in canine liver and kidneys, and can be considered important reference data for diagnostic methods and further investigations.