Fachbereich Veterinärmedizin



    Concentrations of Strontium, Barium, Cadmium, Copper, Zinc, Manganese, Chromium, Antimony, Selenium, and Lead in the Liver and Kidneys of Dogs According to Age, Gender, and the Occurrence of Chronic Kidney Disease (2015)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Passlack, Nadine (WE 4)
    Mainzer, Barbara
    Lahrssen-Wiederholt, Monika
    Schafft, Helmut
    Palavinskas, Richard
    Breithaupt, Angele (WE 12)
    Zentek, Jürgen (WE 4)
    Journal of veterinary science / The Korean Society of Veterinary Science; 16(1) — S. 57–66
    ISSN: 1229-845x
    URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000022272
    Pubmed: 25234328
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    +49 30 838 62450

    Abstract / Zusammenfassung

    This study was conducted to measure the concentrations of strontium (Sr), barium (Ba), cadmium (Cd), copper (Cu), zinc (Zn), manganese (Mn), chromium (Cr), antimony (Sb), selenium (Se), and lead (Pb) in canine liver, renal cortex, and renal medulla, and the association of these concentrations with age, gender, and occurrence of chronic kidney disease (CKD). Tissues from 50 dogs were analyzed using inductively coupled plasma mass spectrometry. Cu, Zn, and Mn levels were highest in the liver followed by the renal cortex and renal medulla. The highest Sr, Cd, and Se concentrations were measured in the renal cortex while lower levels were found in the renal medulla and liver. Female dogs had higher tissue concentrations of Sr (liver and renal medulla), Cd (liver), Zn (liver and renal cortex), Cr (liver, renal cortex, and renal medulla), and Pb (liver) than male animals. Except for Mn and Sb, age-dependent variations were observed for all element concentrations in the canine tissues. Hepatic Cd and Cr concentrations were higher in dogs with CKD. In conclusion, the present results provide new knowledge about the storage of specific elements in canine liver and kidneys, and can be considered important reference data for diagnostic methods and further investigations.