Fachbereich Veterinärmedizin



    Experimental infection of sheep and goats with a recent isolate of peste des petits ruminants virus from Kurdistan (2014)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Wernike, Kerstin
    Eschbaumer, Michael
    Breithaupt, Angele (WE 12)
    Maltzan, Julia
    Wiesner, Henning
    Beer, Martin
    Hoffmann, Bernd
    Veterinary Microbiology; 172(1-2) — S. 140–145
    ISSN: 0378-1135
    DOI: 10.1016/j.vetmic.2014.05.010
    Pubmed: 24908276
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    Tel.+49 30 838 62450 Fax.+49 30 838 62522

    Abstract / Zusammenfassung

    Peste des petits ruminants (PPR) is a contagious viral disease of sheep and goats common in Africa and Asia. Its high morbidity and mortality has a devastating impact on agriculture in developing countries. As an example, an Asian lineage IV strain of PPRV was responsible for mass fatalities among wild goats in Kurdistan in 2010/2011. In separate experiments, three sheep and three goats of German domestic breeds were subcutaneously inoculated with the Kurdish virus isolate; three uninfected sheep and goats were housed together with the inoculated animals. All inoculated animals, all in-contact goats and two in-contact sheep developed high fever (up to 41.7 °C), depression, severe diarrhea, ocular and nasal discharge as well as ulcerative stomatitis and pharyngitis. Infected animals seroconverted within a few days of the first detection of viral genome. Clinical signs were more pronounced in goats; four out of six goats had to be euthanized. Necropsy revealed characteristic lesions in the alimentary tract. Peste des petits ruminants virus (PPRV) RNA was detected in blood as well as nasal, oral and fecal swabs and tissues. The 2011 Kurdish strain of PPRV is highly virulent in European goats and spreads easily to in-contact animals, while disease severity and contagiosity in sheep are slightly lower. PPRV strains like the tested recent isolate can have a high impact on small ruminants in the European Union, and therefore, both early detection methods and intervention strategies have to be improved and updated regularly.